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Pharmaceuticals Optimize Performance

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Pharmaceuticals optimize performance

 

Endress+Hauser ProMass F Coriolis Flowmeter solves deviation and compliance challenges

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A global pharmaceutical manufacturer of generic drugs is required to have an accurate flow measurement solution to meet its pan coating application needs. During the spray and dry process of pan coating, the customer coats generic  drug tablets with a solvent solution. This coating process is carefully monitored for potential entrained gas within the pressurized slurry tanks, where nitrogen causes frequent deviation.

TriNova was brought in by this manufacturer to provide onsite calibration services using our portable flow rig, to confirm the meters they were using from a third party manufacturer were stable. These meters, unfortunately, did not pass calibration tests. TriNova went on to interview all departments involved with these production suites to fully understand the issue, document the current results, and pinpoint the root-cause of the failed tests.

The Challenge: The pharmaceutical manufacturer needed an accurate solution that better fit its application needs, as its current instruments did not. Incorrect measurement from these outdated, third-party metering devices posed a major obstacle for the customer, as the meters required frequent rezeroing between batches. For example, if the meter failed the spray nozzle test, a technician would have to investigate the failure, causing calibration to halt production, rezero the meters with water, retest, and proceed coating the batch. Moreover, the solution must remain FDA compliant during inspections.

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Our Solution: Proline ProMass F Coriolis Flowmeter

TriNova collaborated with the customer to ensure the flow measurement solution fit the customer’s specific coating application needs. TriNova was able to provide a solution with the E+H Proline ProMass F Coriolis Flowmeter with Ethernet/IP. The mass meter was required to measure and control the amount of solution pumped into the spray-dry nozzles, which apply the thin coating to the tablets they manufacture. This instrument provides the customer consistent measurement results, eliminating the need for frequent rezeroing and process downtime. The ProMass Coriolis Flowmeter also allows the customer to quickly resolve deviation issues while remaining FDA compliant.

Solution Details: The ProMass F 100  is the flowmeter with premium accuracy, robustness and extended transmitter functionality. It has a long standing reputation as a highly accurate device under varying process conditions. It is suited for a broad range of applications. Combined with the ProMass F 100 transmitter with two line display and extended functionality like software options for filling and dosing, concentration measurement or advanced diagnostics, ProMass F 100 offers premium accuracy in measurement of liquids and gases.

Results: After installation of the Promass 100 F, the pharmaceuticals company increased uptime to meet production requirements and saw consistent results. Furthermore, the mass flow method resolved deviations more efficiently than the previous scale method.

Anna Watson2022-11-28T18:48:51+00:00

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